MYELOID NEOPLASIA Revised International Prognostic Scoring System for Myelodysplastic Syndromes
نویسندگان
چکیده
Peter L. Greenberg,1 Heinz Tuechler,2 Julie Schanz,3 Guillermo Sanz,4 Guillermo Garcia-Manero,5 Francesc Solé,6 John M. Bennett,7 David Bowen,8 Pierre Fenaux,9 Francois Dreyfus,10 Hagop Kantarjian,5 Andrea Kuendgen,11 Alessandro Levis,12 Luca Malcovati,13 Mario Cazzola,13 Jaroslav Cermak,14 Christa Fonatsch,15 Michelle M. Le Beau,16 Marilyn L. Slovak,17 Otto Krieger,18 Michael Luebbert,19 Jaroslaw Maciejewski,20 Silvia M. M. Magalhaes,21 Yasushi Miyazaki,22 Michael Pfeilstöcker,2 Mikkael Sekeres,20 Wolfgang R. Sperr,15 Reinhard Stauder,23 Sudhir Tauro,24 Peter Valent,15 Teresa Vallespi,25 Arjan A. van de Loosdrecht,26 Ulrich Germing,11 and Detlef Haase3
منابع مشابه
High flow cytometric scores identify adverse prognostic subgroups within the revised international prognostic scoring system for myelodysplastic syndromes.
The estimation of survival of myelodysplastic syndromes (MDS) and risk of progression into acute myeloid leukaemia is challenging due to the heterogeneous clinical course. The most widely used prognostic scoring system (International Prognostic Scoring System [IPSS]) was recently revised (IPSS-R). The aim of this study was to investigate the prognostic relevance of flow cytometry (FC) in the co...
متن کاملThe multifaceted nature of myelodysplastic syndromes: clinical, molecular, and biological prognostic features.
The myelodysplastic syndromes (MDS) consist of a heterogeneous spectrum of myeloid clonal hemopathies. The Revised International Prognostic Scoring System (IPSS-R) provides a recently refined method for clinically evaluating the prognosis of patients with MDS. Molecular profiling has recently generated extensive data describing critical hematopoietic molecular and biologic derangements contribu...
متن کاملImpact of the revised International Prognostic Scoring System, cytogenetics and monosomal karyotype on outcome after allogeneic stem cell transplantation for myelodysplastic syndromes and secondary acute myeloid leukemia evolving from myelodysplastic syndromes: a retrospective multicenter study of the European Society of Blood and Marrow Transplantation.
The aim of this study was to determine the impact of the revised 5-group International Prognostic Scoring System cytogenetic classification on outcome after allogeneic stem cell transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia who were reported to the European Society for Blood and Marrow Transplantation database. A total of 903 patients had suffici...
متن کاملMyeloid Cell Leukemia-1 Gene Expression and Clinicopathological Features in Myelodysplastic Syndrome
Background and Aims: Myeloid cell leukemia-1 (Mcl-1) plays a pivotal role in the survival of hematologic and solid tumors, and is known as a substantial oncogene. Studies have demonstrated the altered expression of Mcl-1 has been linked to malignancy development and poor prognosis. In this research, we have studied the expression of Mcl-1 mRNA in myelodysplastic syndrome (MDS) patients and det...
متن کاملComplex or monosomal karyotype and not blast percentage is associated with poor survival in acute myeloid leukemia and myelodysplastic syndrome patients with inv(3)(q21q26.2)/t(3;3)(q21;q26.2): a Bone Marrow Pathology Group study.
Acute myeloid leukemia and myelodysplastic syndrome with inv(3)(q21q26.2)/t(3;3)(q21;q26.2) have a poor prognosis. Indeed, the inv(3)(q21q26.2)/t(3;3)(q21;q26.2) has been recognized as a poor risk karyotype in the revised International Prognostic Scoring System. However, inv(3)(q21q26.2)/t(3;3)(q21;q26.2) is not among the cytogenetic abnormalities pathognomonic for diagnosis of acute myeloid le...
متن کاملScientific comment on tumor suppressor p53 protein expression: prognostic significance in patients with low-risk myelodysplastic syndrome
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic neoplasms, characterized by dysplastic findings with variable degree of bone marrow failure and proliferation of blast cells.1 It is the most common neoplastic disease of the bone marrow, with an estimated incidence of 1.3–5 per 100,000 people annually, and reaching 36 per 100,000 in patients aged 80 years or over...
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